Episodes
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AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge
Healthcare AI solutions must prioritize safety, accuracy, and reliability given the high stakes involved in patient care.
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⚡️ Senior Dev: This "Grill Me" Prompt Is Going Viral Among Top Engineers
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🔬 Doing Vibe Physics — Alex Lupsasca, OpenAI
AI models, especially advanced GPT versions, have reached a point where they can significantly accelerate and even lead cutting-edge scientific research in physics.
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⚡️ Competing with ChatGPT and Sierra, building a $10M ARR company — Yasser Elsaid, Founder, Chatbase
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Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition
Applied Intuition's mission is to develop physical AI to make moving machines safer and more efficient across industries like transportation, construction, and defense.
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AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)
The AI ecosystem is currently focused on infrastructure stability, model iteration, and engineering practices, with a belief that foundational stability is approaching.
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Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO
Shopify is aggressively adopting AI across its entire workflow, from internal tooling to customer-facing systems, driven by a rapid improvement in models especially after the December 2022 inflection point.
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🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik
Successful cancer treatment development relies heavily on understanding tumor heterogeneity and precise patient stratification.
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⚡️ How to turn Documents into Knowledge: Graphs in Modern AI — Emil Eifrem, CEO Neo4J
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Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion
Notion’s AI journey has been iterative, with multiple rebuilds driven by rapidly evolving frontier capabilities and model limitations.
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⚡️ The best engineers don't write the most code. They delete the most code. — Stay Sassy
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Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony
AI harness engineering enables the development of autonomous, scalable software organizations driven by AI agents without human code writing.
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Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"
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Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun
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Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample
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🔬 Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik
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Dreamer: the Personal Agent OS — David Singleton
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Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop
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⚡️ Monty: the ultrafast Python interpreter by Agents for Agents — Samuel Colvin, Pydantic
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Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer
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